Phytonadione Injection

Important warning:

Phytonadione injection may cause serious or life-threatening allergic reactions, which usually occur during or shortly after the injection of the medication. If you experience any of the following symptoms, tell your doctor immediately: rash; hives; itching; flushing; difficulty breathing; shortness of breath; weakness; bluish color around the mouth, fingers, or fingernails; chest pain; sweating; or fast heartbeat.

Why is this medicine prescribed?

Phytonadione injection is used to prevent bleeding in people with blood clotting problems or toolittle vitamin K in the body. Phytonadione injection is also used to prevent and treat bleeding in newborn babies. Phytonadione is in a class of medicationscalled vitamins. It works by providing vitamin K that is needed for blood to clot normally in the body.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Phytonadione Injection comes as a liquid to be injected subcutaneously (under the skin), intramuscularly (in a muscle), or intravenously (into a vein) by a doctor or nurse. It is given as a single dose. Additional doses may be given depending on your response to the medication.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What special precautions should I follow?

Before receiving phytonadione injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving phytonadione injection. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving phytonadione injection, call your doctor.

• ifyou are having surgery, including dental surgery, tell the doctor or dentistthat you are receiving phytonadione injection

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medicine cause?

Phytonadione injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• redness, pain, tenderness, or swelling at the injection site
• change in the sense of taste
• dizziness
• dry, scaly, itchy skin

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

• unusual bruising or bleeding

Phytonadione injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• yellowing of the skin or eyes in newborn babies

What other information should I know?

Keep all appointments with your doctor and laboratory. Your doctor may order certain tests to check your response to phytonadione injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

Other name(s)

• Vitamin K

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2026. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: February 15, 2026.